彭敏博士在免疫代谢和营养信号转导方面进行了深入的研究，发现多种调控营养信号转导的关键分子以及代谢通路调控免疫细胞分化的分子机制，相关研究成果发表在Cell、Nature及Science等国际学术期刊，并获得“求是”杰出青年学者奖。目前， 彭敏博士致力于使用高通量功能基因组学技术系统性地研究T淋巴细胞增殖分化的调控机理以及细胞代谢调节免疫应答等的分子机制，并利用这些分子机理为免疫相关疾病的诊断和治疗提供新策略和新靶点。

实验室研究方向：

T cells play essential roles in immune response. We are studying T cells with two directions:

1. Functional genomics in primary T cells

We are applying genome-wide CRISPR/Cas9 screen in primary T cell in vivo to answer fundamental questions in T cell biology, including development, activation, proliferation and differentiation, as well as T cell fitness (e.g. exhaustion) in tumor microenvironment.  Identified novel genes and regulatory circuits have been used to design novel therapies for diseases.

2. Mechanisms of metabolic regulation of T cells

Metabolic reprogramming is a hallmark of T cell activation, but how metabolic pathways regulate T cell function remains poorly understood. We are using mouse models with gain- and loss-of-function of key metabolic enzymes to decipher metabolic regulation T cell, and try to target metabolism to treat immune-related diseases.

参考文献：

1. Hanfei Zhao, Ying Liu, Lixia Wang, Gang Jin, Xiaocui Zhao, Jing Xu, Guangyue Zhang, Yuying Ma, Na Yin, Min Peng. Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity. Cell Reports. 2021 Dec 7;37(10):110083.

2. Ke Xu*, Na Yin*, Min Peng, Efstathios G Stamatiades, Sagar Chhangawala, Amy Shyu, Peng Li, Xian Zhang, Mytrang H Do, Kristelle J Capistrano, Chun Chou, Christina S Leslie, Ming O Li. Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses. Immunity. 2021. 54(5):976-87.  

3. Ke Xu, Na Yin, Min Peng, Efstathios G Stamatiades, Amy Shyu, Peng Li, Xian Zhang, Mytrang H Do, Zhaoquan Wang, Kristelle J Capistrano, Chun Chou, Andrew G Levine, Alexander Y Rudensky, Ming O Li. Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity. Science. 2021.371(6527):405-10.

4. Min Peng*, Na Yin*, Sagar Chhangawala, Ke Xu, Christina S. Leslie, Ming O. Li. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science. 2016 Oct 28; 354(6311): 481-484.

Preview in Science, 2016 Oct 28; 354(6311): 419-420. “Warburg meets epigenetics”.

Preview in Dev Cell, 2016 November 7;39: 286-287. “Metabolic Control of Cellular Differentiation”.

Preview in Cell Metab, 2016 November 8; 24: 651-652. “Metabolic Signaling Drives IFN-g”.

5. Min Peng, Na Yin, Ming O. Li. SZT2 dictates GATOR control of mTORC1 signaling. Nature. 2017 Mar 16;543(7645):433-437.

6. Min Peng, Na Yin, Ming O. Li. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell. 2014 Sep 25; 159(1): 122-33.

博士后招聘

CAR-T肿瘤治疗方向2名：

应聘条件：具有免疫学、分子和细胞生物学相关专业博士学位，获得博士学位2年以内；近期以第一作者身份在国际知名学术期刊发表研究论文，符合清华大学博士后入站标准；热爱科研工作，责任心强，具备团队合作精神；具备较好的英语沟通、阅读和写作能力。

岗位待遇： 岗位待遇按照清华大学相关规定执行。课题组将根据工作情况提供一定生活补助和绩效奖励。另外，根据本单位相关规定，博士后以第一作者、清华大学为第一单位发表高水平学术期刊可获得有非常有竞争力的绩效奖励（http://postdoctor.tsinghua.edu.cn/）。

申请方式：将简历（包括学历和论文发表情况）、研究自述（研究兴趣、成果以及未来职业规划）、及2-3名推荐人的联系方式发至：pengmin@tsinghua.edu.cn；主题标明“姓名+应聘博士后+高校人才网“。

信息来源于网络，如有变更请以原发布者为准。

来源链接：

http://www.cls.edu.cn/Careers/Postdoctoral5565.shtml

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